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Harmony Neuro Behavioral Care
Service

Spravato (Esketamine) Treatment

Introduction

Spravato (esketamine) is an FDA-approved nasal spray for treatment-resistant depression, used alongside an oral antidepressant. Unlike traditional medications that can take weeks to show any effect, many patients notice meaningful improvement in mood within days of starting treatment.

What Contributes to This

Spravato may be a fit if:

  • You've tried two or more standard antidepressants without adequate relief
  • Depression is significantly affecting your daily functioning despite ongoing treatment
  • You and your provider are looking for a faster-acting option alongside therapy and medication

How Can We Help?

Every Spravato treatment is administered in-office under direct clinical supervision, following the FDA-mandated monitoring protocol.

01

Eligibility Consultation

We review your treatment history together to confirm Spravato is an appropriate, safe next step — and walk through exactly what to expect before your first dose.

02

Supervised In-Office Dosing

You self-administer the nasal spray in our office under direct observation, then remain on-site for monitoring — the full visit typically runs about two hours.

03

Built-In Safety Monitoring

Your blood pressure and how you're feeling are checked at regular intervals during the monitoring period, per FDA requirements, before you're cleared to leave with a ride home.

04

A Coordinated Treatment Plan

Spravato sessions are paired with your ongoing oral antidepressant and therapy, with dosing frequency adjusted over time as your symptoms respond.